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KMID : 0606920170250040345
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Biomolecules & Therapeutics
2017 Volume.25 No. 4 p.345 ~ p.353
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Production of Recombinant Anti-Cancer Vaccines in Plants
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Lee Jeong-Hwan
Ko Ki-Sung
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Abstract
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Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants. Specifically, the issues such as low expression levels and plant-specific glycosylation are described, along with their potential solutions.
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KEYWORD
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Cancer, Vaccine, Glycosylation, Plant expression system, Subunit vaccine, Recombinant protein
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